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Open Access Highly Accessed Review

Research progress on surface antigen 1 (SAG1) of Toxoplasma gondii

Yanhua Wang* and Hong Yin

Author Affiliations

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China

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Parasites & Vectors 2014, 7:180  doi:10.1186/1756-3305-7-180

Published: 13 April 2014

Abstract

Toxoplasma gondii is an obligate intracellular parasitic protozoan that has a wide host range and causes a zoonotic parasitosis called toxoplasmosis. This infection causes significant morbidity, costs for care and loss of productivity and suffering. The most effective measures to minimize this parasite’s harm to patients are prompt diagnosis and treatment and preventing infection. A parasite surface antigen, SAG1, is considered an important antigen for the development of effective diagnostic tests or subunit vaccines. This review covers several aspects of this antigen, including its gene structure, contribution to host invasion, mechanisms of the immune responses and its applications for diagnosis and vaccine development. This significant progress on this antigen provides foundations for further development of more effective and precise approaches to diagnose toxoplasmosis in the clinic, and also have important implications for exploring novel measures to control toxoplasmosis in the near future.

Keywords:
T. gondii; Surface antigen 1; Gene structure; Invasion; Diagnosis; Vaccine