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Open Access Highly Accessed Research

Ultra low concentration deltamethrin loaded patch development and evaluation of its repellency against dengue vector Aedes (S) albopictus

Pronobesh Chattopadhyay1, Sunil Dhiman2*, Kangujam Adiya Devi3, Subham Banerjee1, Bipul Rabha2, Ashwani Chaurasia1 and Vijay Veer2

Author Affiliations

1 Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur, Assam 784 001, India

2 Division of Medical Entomology, Defence Research Laboratory, Tezpur, Assam 784 001, India

3 Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati, Assam 781017, India

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Parasites & Vectors 2013, 6:284  doi:10.1186/1756-3305-6-284

Published: 28 September 2013

Abstract

Background

Mosquito repellents and emanators confer protection against mosquito bites through spatial action of emanated vapours which are released into the adjoining environment. Synthetic insecticides released into the environment in ultra low volume vapour phase deter the mosquitoes from biting humans in a protected space.

Methods

Formulation patches were prepared using the solvent evaporation method over a backing membrane and using Dibutylphthalate (DBT) as a plasticizer. The effect of formulation variables on the deltamethrin release from the patch matrices were studied under accelerated conditions, whereas, HPLC was used for quantitative estimation of deltamethrin. The prepared patch formulations were subjected to physicochemical studies, such as, deltamethrin content, thickness, weight variation, percent moisture content, moisture uptake, surface area and surface pH determination. Deltamethrin-polymer interaction and compatibility was ascertained using DSC and FT-IR, while surface morphology and deltamethrin distribution in the patch were studied using SEM technique. Repellent activity of the patch formulations was evaluated against Ae. albopictus mosquitoes.

Results

Blends of polymeric combinations of polyvinylpyrrolidone (PVP) and ethyl-cellulose (EC) with admixture of deltamethrin provided prolonged repellent activity against Ae. albopictus mosquitoes. Physicochemical characterisation indicated the suitability of deltamethrin patch formulation with the polymeric combinations of PVP and EC. Patches were very effective against laboratory reared Ae. albopictus mosquitoes. No significant difference was observed between the performance of test patches and commercially available repellent cream MosqshieldĀ®.

Conclusion

Deltamethrin loaded patches provided effective repellency against Ae. albopictus mosquitoes. The study emphasised that deltamethrin released to the environment in low concentration could be an excellent spatial repellent against hematophagous mosquitoes.

Keywords:
Deltamethrin; Mosquito repellent; Patch; HPLC; Aedes (Stegomyia) albopictus