Table 2

Effect of silymarin with/without praziquantel on liver function tests, 10 and 18 weeks post-infection of mice with S.mansoni

Animal groups

Serum ALT

(U/L)

Serum albumin

(g/dl)

Hepatic GSH

(mg/g liver)


10 wks

18 wks

10 wks

18 wks

10 wks

18 wks


Uninfected (vehicle)

22.62 ± 1.82

21.67 ± 0.93

3.75 ± 0.21

3.55 ± 0.23

6.00 ± 0.29

5.92 ± 0.26


Infected (Vehicle)

††

40.71 ± 4.07

†††

32.57 ± 1.94

3.27 ± 0.10

††

2.69 ± 0.07

†††

2.80 ± 0.22

†††

2.12 ± 0.21


Infected + PZQ

††‡

30.57 ± 1.25

‡‡

23.17 ± 1.76

3.35 ± 0.09

‡‡

3.08 ± 0.07

†††‡

3.40 ± 0.13

†††‡‡‡

4.07 ± 0.29


Infected + silymarin

†††

39.75 ± 3.57

‡†

26.80 ± 2.00

3.22 ± 0.07

2.90 ± 0.05

††‡‡

4.43 ± 0.32

†††‡‡

3.18 ± 0.22


Infected + PZQ + silymarin

‡‡

25.88 ± 1.41

‡‡‡

19.75 ± 1.56

3.35 ± 0.12

3.17 ± 0.19

‡‡§§

5.90 ± 0.68

†‡‡‡§

4.99 ± 0.19


Data are presented as mean ± SEM (n = 8 in each group).

Mice were administered praziquantel (PZQ; 500 mg/kg/day for 2 days) in the 7th week post infection (PI) and silymarin (750 mg/kg/day, 5 days/week for 6 weeks) at the 4th and 12th weeks PI for 6 weeks and were killed 10 and 18 weeks PI respectively.

ALT, Alanine aminotransferase; GSH, reduced glutathione.

† Significantly different from uninfected (vehicle) group at P < 0.05, †† at P < 0.01 and ††† at P < 0.001. ‡ Significantly different from infected (vehicle) group at P < 0.05, ‡‡ at P < 0.01 and ‡‡‡ at P < 0.001. § Significantly different from infected treated with PZQ group at P < 0.05 and §§ at P < 0.01.

El-Lakkany et al. Parasites & Vectors 2012 5:9   doi:10.1186/1756-3305-5-9

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