Table 1

Effect of silymarin with/without praziquantel on total worms, hepatic tissue egg load and % dead eggs 10 and 18 weeks post infection of mice with S.mansoni

Animal groups

Total worms

Hepatic tissue egg load × 103

% dead eggs


10 wks

18 wks

10 wks

18 wks

10 wks

18 wks


Infected (Vehicle)

19.16 ± 2.18

20.28 ± 0.99

16.22 ± 1.40

27.08 ± 3.53

7.16 ± 0.94

6.87 ± 0.99


Infected + PZQ

‡‡‡

0.80 ± 0.17

(95.82%)

‡‡‡

0.50 ± 0.27

(97.53%)

‡‡‡

4.00 ± 0.43

(75.34%)

‡‡‡

7.64 ± 1.10

(71.79%)

‡‡‡

100 ± 0.00

‡‡‡

100 ± 0.00


Infected + silymarin

14.13 ± 2.96

(26.25%)

‡‡‡

12.29 ± 1.21

(39.39%)

‡‡

11.56 ± 0.68

(28.73%)

‡‡

15.40 ± 0.72

(43.13%)

11.00 ± 0.97

‡‡‡

39.29 ± 2.60


Infected + PZQ + silymarin

‡‡‡

0.50 ± 0.50

(97.39%)

‡‡‡

0.00 ± 0.00

(100%)

‡‡‡

3.67 ± 0.60

(77.37%)

‡‡‡

6.14 ± 0.76

(77.33%)

‡‡‡

100 ± 0.00

‡‡‡

100 ± 0.00


Data are presented as mean ± SEM (n = 8 in each group).

Mice were administered praziquantel (PZQ; 500 mg/kg/day for 2 days) in the 7th week post infection (PI) and silymarin (750 mg/kg/day, 5 days/week for 6 weeks) at the 4th and 12th weeks PI for 6 weeks and were killed 10 and 18 weeks PI respectively. Numbers in parentheses indicate the percentage of reduction from infected (vehicle) group.

‡ Significantly different from infected (vehicle) group at P < 0.05, ‡‡ P < 0.01 and ‡‡‡ at P < 0.001.

El-Lakkany et al. Parasites & Vectors 2012 5:9   doi:10.1186/1756-3305-5-9

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