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Open Access Highly Accessed Review

Implication of haematophagous arthropod salivary proteins in host-vector interactions

Albin Fontaine1, Ibrahima Diouf1, Nawal Bakkali1, Dorothée Missé2, Frédéric Pagès3, Thierry Fusai1, Christophe Rogier14 and Lionel Almeras1*

Author Affiliations

1 Unité de Parasitologie - UMR6236 - IFR48, Antenne Marseille de l'Institut de Recherche Biomédicale des Armées (IRBA), Le Pharo, BP 60109, 13 262 Marseille Cedex 07, France

2 Laboratoire de Génétique et Evolution des Maladies infectieuses, UMR 2724 CNRS/IRD, Montpellier, France

3 Unité d'Entomologie Médicale, Antenne Marseille de l'Institut de Recherche Biomédicale des Armées (IRBA), Le Pharo, BP 60109, 13 262 Marseille Cedex 07, France

4 Institut Pasteur de Madagascar, B.P. 1274, Ambohitrakely, 101 Antananarivo, Madagascar

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Parasites & Vectors 2011, 4:187  doi:10.1186/1756-3305-4-187

Published: 28 September 2011

Abstract

The saliva of haematophagous arthropods contains an array of anti-haemostatic, anti-inflammatory and immunomodulatory molecules that contribute to the success of the blood meal. The saliva of haematophagous arthropods is also involved in the transmission and the establishment of pathogens in the host and in allergic responses. This survey provides a comprehensive overview of the pharmacological activity and immunogenic properties of the main salivary proteins characterised in various haematophagous arthropod species. The potential biological and epidemiological applications of these immunogenic salivary molecules will be discussed with an emphasis on their use as biomarkers of exposure to haematophagous arthropod bites or vaccine candidates that are liable to improve host protection against vector-borne diseases.