Research
The nature and combination of subunits used in epitope-based Schistosoma japonicum vaccine formulations affect their efficacy
- † Equal contributors
1 Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 210029, PR China
2 Central Laboratory of the Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu 212002, PR China
3 Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, KAM 100B, Los Angeles, CA 90089, USA
Parasites & Vectors 2010, 3:109 doi:10.1186/1756-3305-3-109
Published: 19 November 2010Additional files
Additional file 1:
Schematic diagram of forming a PDDV. A cationic antigenic peptide containing 18 lysines (18K) and the antigenic epitope was designed and synthesized. An anionic plasmid containing the DNA sequence of the corresponding antigenic epitope sequence and mouse GM-CSF was constructed. The cationic peptides and corresponding anionic plasmids form virus-like particles through electrostatic interactions at an appropriate charge ratio of peptide and DNA.
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