This article is part of the supplement: Equine parasites: diagnosis and control - a current perspective
Equine cyathostomins: a review of biology, clinical significance and therapy
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Correspondence: Susan Corning cornins@fdah.com
Parasites & Vectors 2009, 2(Suppl 2):S1 doi:10.1186/1756-3305-2-S2-S1
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Research
César A Ramírez, José M Requena, Concepción J Puerta Parasites & Vectors 2011, 4:166 (26 August 2011) The HSP70 locus in Leishmania braziliensis, characterised in this study, is composed of two types of genes (HSP70-I and HSP70-II) tandemly organized in a head-to-tail manner. The HSP70-I mRNA levels, contrary to those observed in other Leishmania species, are not affected by heat shock. Image: Leishmania braziliensis HSP70 gene cluster: genomic structure and UTR characterization.
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Research
Javier Carrión, Cristina Folgueira, Manuel Soto, Manuel Fresno, Jose M Requena Parasites & Vectors 2011, 4:150 (27 July 2011) This study describes the ability of a Leishmania infantum deletion mutant, lacking both HSP70-II alleles (ΔHSP70-II), to provide protection against L. major in the BALB/c infection model. Furthermore, ΔHSP70-II could be a safe live vaccine as administration to SCID mice and hamsters (Mesocricetus auratus) did not develop any sign of pathology. Image:Pre-inoculation of mice with ΔHSP70-II promastigotes prevented footpad lesion development after a challenge with virulent L. major.
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